E. fischeriana Root Compound Dpo Activates Antiviral Innate Immunity

E. fischeriana Root Compound Dpo Activates Antiviral Innate Immunity

E. fischeriana has long been used as a traditional Chinese medicine. Recent studies reported that some compounds of E. fischeriana exhibited antimicrobial and immune enhance activity. Innate immune system is essential for the immune surveillance of inner and outer threats, initial host defense responses and immune modulation. The role of natural drug compounds, including E. fischeriana, in inna...

Mitochondria and antiviral innate immunity.

Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the par...

Sensing and Signaling in Antiviral Innate Immunity

Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to vira...

SnapShot: Pathways of Antiviral Innate Immunity

MAVS Coordination of Antiviral Innate Immunity.

RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to trigger the antiviral innate immune response. Here, we describe how MAVS subcellular localization impacts its function and the regulation underlying MAVS signaling. We propose a model to describe how the coordination of MAVS ...